Abstract:

Plant polysaccharides have immune-regulatory function and can be widely used in medical and health food
industries as immunomodulatory agents. Nuclear factor kappa B (NF-κB), as one of the nuclear factors regulating gene
transcription, plays a critical role in the regulation of multiple genes in macrophages. Many studies have shown that plant
polysaccharides induce immune response of macrophages through NF-κB signaling pathway. This review describes the
composition and regulation of NF-κB signaling pathway as well as the mechanism of NF-κB activation by the plant
polysaccharide-mediating receptor on the surface of macrophages. This review can provide a reference for further study of
plant polysaccharides.

Key words: plant polysaccharide, nuclear factor kappa B, signaling pathway, macrophages, immune regulation