Abstract:

The phosphatidylinositol 3-kinase/serine/threonine kinase B (PI3K/Akt) signaling pathway is a classical signaling
pathway that inhibits apoptosis and promotes proliferation. The PI3K/Akt pathway play an important role in cancer,
cardiovascular disease, diabetes and nervous system diseases, especially in cancer. The abnormal activation of PI3K/Akt is
closely related to the occurrence, invasion and metastasis of tumors. The research of this pathway has become the focus of
the treatment of cancer at home and abroad. Plant polyphenols are becoming natural drugs to prevent cancer because of their
anti-tumor effect. This review outlines the structure and activation mechanism of the PI3K/Akt signaling pathway and its
relationship with tumor in order to provide scientific evidence for the development of plant polyphenols into health foods or
drugs for cancer prevention.

Key words: phosphatidylinositol 3-kinase/serine/threonine kinase B (PI3K/Akt), signaling pathway, plant polyphenols, antitumor