Abstract: In order to explore the anti-aging effects of new dietary patterns, an aging mouse model was established by subcutaneous injection of 100 g/L D-galactose solution for 9 weeks, and starting from the 9th week, the mice were fed with Bama dietary patterns and simultaneously administered orally with a mixture of two probiotics, Lactobacillus casei LT-L614 and Lactobacillus fermentans LT-P132 (1:1, V/V) with a viable cell count of 109 CFU/mL at a dose of 0.2 mL/20 g body mass for another 9 weeks. The locomotor activity, sensorimotor capacity, neuromuscular coordination and anxiety status of the mice were measured by the open field test and the tight-rope test in week 18. The results showed that in the open field test, compared with the aging model group, Bama characteristic dietary pattern II significantly increased the number of hind limb stand by 131.91% (P < 0.05) and the number of squares crossed by 19.71% (P > 0.05), and prolonged the total activity time to (273.72 ± 8.78) s (P < 0.05). Bama characteristic dietary patterns II and III increased the time spent in the center of the open field by 73.46% and 116.60% (P < 0.05), respectively. In the tight-rope test, compared with the control group, Bama characteristic dietary patterns II and III extended the suspension time up to (58.90 ± 4.74) and (57.67 ± 6.28) s (P > 0.05), respectively, and the conversion score by 43.66% and 39.33% (P < 0.05). Compared with the aging model group, the suspension time was prolonged by 51.92% and 48.75% (P < 0.05), respectively, and the conversion score by 154.47% and 146.79% (P < 0.05), respectively. Conclusion: The Bama characteristic dietary patterns can effectively improve the movement coordination ability and antianxiety ability of aging mice. Among them, dietary patterns II and III are the most effective, and can significantly reverse the decline of exercise capacity of D-galactose-induced aging mice.

Key words: Bama characteristic dietary patterns, D-galactose, exercise capacity, antianxiety level