Abstract: Objective: To study oxidative damage of mice heart induced by omethoate. Methods: The mice were divided into 8 groups(control 1 group, vitamin E 2 group, vitamin C 3 group, 2.5mg/kg omethoate 4 group, 5mg/kg omethoate 5 group, 10mg/kg omethoate6 group, 10mg/kg omethoate+800mg/kg vitamin E 7 group and 10mg/kg omethoate+400mg/kg vitamin C 8 group,with 12mice/group)and perfusion fed for 7d. Results: The activities of SOD in heart were decreased with dosage increasing of omethoate, and in 10mg/kg omethoate group ,the activities of SOD were significantly decreased than those in control group. MDA increased sighificantlyat 10mg/kg omethoate and showed obvious positive correlationship between omethoate doses and MDA. Vitamin E and vitamin Ccould inhibite the decrease of SOD activities and increase of MDA. Conclusion: Omethoate could induce lipid peroxidation in heartof mice. Vitamin E and vitamin C could prevent oxidative damage of heart induced by omethoate to a certain degree.

Key words: omethoate, oxidative damage, mice, heart, antioxidative vitamin