Abstract: Objection: To investigate the immunity function and anti-oxidation activity of phycobiliproteins from Gracilaria Lemaneiformis in mice. Methods: The mice was treated by Gastric incubation with the crude phycobiliproteins, which were got from Gracilaria Lemaneiformis by ammonium sulfate precipitation, at doses of 100、200、300mg/kg/d .The phagocytosing function of celiac macrophage, the spleen index and the thymus index, the activity of erythrocyte superoxide dismutase (SOD) and the content of serum lipoid peroxide (LPO) in mice respectively were determined on the 15th day and 30th day of the treatment. Result: The crude phycobiliprotens could significantly improve the phagocytosing function of celiac macrophage, and stimulate the growth of spleen and thymus; and also can increased the activity of erythrocyte SOD and decreased the content of LPO significantly. Conclusion: The crude phycobiliproteins from Gracilaria Lemaneiformis has the abilities to increasing theimmunity function and anti-oxidation activity in mice.

Key words: Gracilaria Lemaneiformis, phycobiliproteins, immunity function, anti-oxidation