Abstract: Sweet tea Lithocarpus polystachyus Rehd has been a traditional Chinese herb and been taken as health drink, tender leaves of which are abundant with flavonoid phloridzin. Four groups of diabetic model mice induced by alloxan were fed respectively with 4 doses of phloridzin (STPh) separated and purified from Lithocarpus polystachyus Rehd for 18d, a group of non-model mice and a group of model mice fed with the same volume water were taken as the controls, and a group of model mice fed with Xiaokewan (a Chinese medicine for diabete) was taken as the positive control. Then levels of serum glucose, TG, TC, MDA, and SOD and GSH-Px activities were investigated. The results showed that by STPh treatment, levels of serum glucose, TG, TC and MDA were significantly reduced, and SOD and GSH-Px activities were apparently enhanced. Among 4 doses of STPh treatments, 70mg/kg bw·d was the modest one.

Key words: Lithocarpus polystachyus Rehd, phloridzin, diabete, serum glucose, serum lipids