Abstract: Objective: To study the inhibitive effect of the active part of the leaves of persimmon on tumor cell lines. Methods: MTT (methylthiazolydiphenyl-tetrazolium bromide) method was taken to detect the anti-tumor activities of the acitve part of the leaves of persimmon after it was extracted from the leaves on Hela and H22 cell lines. And the data was analyzed by SPSS. Results: ①The extract of the leaves of persimmon with water and ethanol had evident inhibition effect on Hela’s growth. ②The extract of the leaves of persimmon with water and ethanol had evident inhibition effect on H22’s growth. ③The extract can change the cellular morphology and growth mode. Conclusion: The extract of leaves of persimmon had evident inhibition effect on Hela and H22 cell in a certain dosage.

Key words: leaves of Persimmon, extractive, inhibition in anti-tumor, MTT