Establishment of Alcohol and Fat-induced Liver Injury Mode in Mouse

Abstract

Abstract: Objective: Establish of alcohol and fat-induced liver injury mode in mouse. Methods: Selected mice were randomly divided into two groups, one was trial group and the other was control group. Optimized portions of alcohol and high-fat feed were administrated gastrically every day for trail group while the same volumes of water and normal feed were applied for control group. After 4 weeks, livers and blood were collected from animals for 2 (MDA and GSH) and 3 (ALT, AST and LDH) assessments, respectively. Results: A significant increase in ALT, AST, LDH and MDA was observed while a reduction of GSH was seen. Conclusion: A supply of alcohol and high-fat feed by gastric administration is able to establish liver injury mode in mouse.

Key words: liver injury mode, mouse

WANG Zheng, ZHANG Jing, HUI Bo-Di. Establishment of Alcohol and Fat-induced Liver Injury Mode in Mouse[J]. FOOD SCIENCE, 2007, 28(8): 478-480.

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Establishment of Alcohol and Fat-induced Liver Injury Mode in Mouse

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