Abstract: This study aimed to investigate the effects of CGMP with different doses on microflora in caecum of mice.126 BALB/c mices were randomly divided into six groups (control groups and treatment groups). The control 1 group was administered only with normal fodder. The control 2 group was administered physiological saline at the dose of 0.2 ml/d. The treatment groups were administered the equal volume of CGMP with different concentrations for 15d. At 0 (before terminating),3,5,7,10,15 and 22 d (after terminating CGMP for 1 week) the microflora in the caecum of the tested mice was analyzed respectively in each group. The results showed that in the middle dose group (100 μg/d),the numbers of Bifidobacterium (p<0.05) and Lactobacillus increase (p<0.01),but those of Enterobacter,Enterococcus,opportunistic pathogenesis decrease (p<0.05),compared with the controls groups. The results prove that appropriate dose of CGMP has the function of regulating the intestinal flora,stimulating Bifidobacterium and Lactobacillus to grow,and inhibiting the growth of pathogenic bacteria.

Key words: CGMP, microflora, caecum, mice