Antidiabetic Effect of Traditional Chinese Medicinal Cyclocarya paliurus Granules in Diabetic Mice

Abstract

Abstract: The antidiabetic effect of Cyclocarya paliurus granules, a traditional Chinese medicine preparation based on Cyclocarya paliurus leaves, in streptozotocin (STZ) induced diabetic mice was evaluated in this study. Diabetes was induced in mice by using STZ. Model control, normal control, positive control and low, medium and high-dose Cyclocarya paliurus granule treatment groups were established. After 12 d of administration, the levels of fasting blood sugar, total cholesterol, triglyceride and hepatic glycogen and body weight in mice were measured. At the same time, histopathological examination of mouse pancreas was carried out to find pathological changes. The results showed that Cyclocarya paliurus granules significantly reduced blood glucose and total cholesterol levels in diabetic mice. In addition, Cyclocarya paliurus granules improved body weight and hepatic glycogen levels. Histopathological examination showed that Cyclocarya paliurus granules promoted the recovery of langerhans islet cells from pancreas necrosis associated with diabetes. All these data suggest that Cyclocarya paliurus granules have therapeutic effects on diabetic mice. The mechanism is probably related to their regulation of hepatic glucose metabolism and the function of langerhans islet cells.

Key words: Cyclocarya paliurus, granules, antidiabetic effect, diabetic mice

CLC Number:

R965

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