Effect of Bacillus subtilis JS01 Ingestion on Intestinal Flora and Lipofuscin in Obese Mice

Abstract

Abstract: This study was undertaken to observe whether or not Bacillus subtilis JS01 ingestion has a positive therapeutic effect on high-fat diet caused intestinal flora disorder, obesity, lipid peroxidation and fat deposition in mice. Male mice were used to create experimental obesity model groups (C through F) and different doses of Bacillus subtilis JS01 were fed to low-, middle- and high-dose intervention groups (D, E and F), respectively. The results showed that Bacillus subtilis JS01 supplementation resulted in a significant reduction in the body weight of intervention group F and in the weight gain of intervention groups E and F. High-fat diet model group C showed an increase in intestinal Bifidobacteria level, a decrease in intestinal Lactobacillus level, remarkable hepatic steatosis, and a rise in hepatic lipofuscin. Oral administration of Bacillus subtilis JS01 could decrease intestinal Bifidobacteria and Lactobacillus levels, relieve hepatic steatosis and reduce hepatic lipofuscin. In conclusion, Bacillus subtilis JS01 can improve high-fat diet caused obesity, intestinal flora disorder, lipid peroxidation and fat deposition in mice.

Key words: Bacillus subtilis, obesity, intestinal flora, lipofuscin

CLC Number:

TS201.3

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