Preventive Effect of Coenzyme Q9 against Oxidative Damage in Human Vascular Endothelial Cells

Abstract

Abstract: Objective: To explore the protective effect of coenzyme Q9 against H2O2-induced oxidative damage in human vascular endothelial cells. Methods: An HUVEC (human umbilical vein endothelial cells) model of H2O2-induced oxidative damage was created by MTT assay and used to study the preventive effect and its mechanism of coenzyme Q9 against H2O2-induced oxidative damage. Results: Coenzyme Q9 at 100 μg/mL could exert preventive and repairing effects against H2O2-induced oxidative damage in HUVEC cells. The mechanism was partially due to that fact that the generation of ROS and MDA was inhibited by coenzyme Q9. Meanwhile, preventive treatment with coenzyme Q9 could effectively protect SOD against H2O2-induced damage but had no repairing effect. Conclusion: Coenzyme Q9 has protective and repairing effects against oxidative damage in human vascular endothelial cells.

Key words: coenzyme Q9, vascular endothelial cell, oxidative damage, protective effect, repairing effect

CLC Number:

References

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