Antioxidant and Anti-tumor Activities of Extracts from Lepista irina

doi:10.7506/spkx1002-6300-200923048

FOOD SCIENCE ›› 2009, Vol. 30 ›› Issue (23): 214-217.doi: 10.7506/spkx1002-6300-200923048

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Antioxidant and Anti-tumor Activities of Extracts from Lepista irina

CHEN Ying1，SUN Hong2，ZHANG Shu-bin2，WANG Li-an2,*

1. College of Biology Science and Engineering, Hebei University of Economics and Business, Shijiazhuang 050061, China；
2. College of Life Science, Hebei Normal University, Shijiazhuang 050016, China

Received:2008-12-09 Revised:2009-04-30 Online:2009-12-01 Published:2010-12-29
Contact: WANG Li-an E-mail:wlian1965@126.com

Abstract

Abstract:

The dried powder of fruit body of Lepista irina (Fr.) Bigelow was extracted with petroleum ether (PE), ethyl acetate (EA), ethanol (Eth) and polysaccharides were prepared. The yield of various extracts was 7.284% (Eth-portion), 2.284% (PEportion), 0.858% (EA-portion) and 4.107% (polysaccharides), respectively. The antioxidant and antitumor properties of solvent extracts were studied by free radical scavenging assay and MTT assay. The results showed that all extracts and polysaccharides provided various antioxidant activities against radicals of DPPH and hydroxyl and EA and Eth extracts possessed the highest effect. MTT data suggest the varying antitumor activities of extracts and the EA extract showed the highest antiproliferative effect (82.7%). The polysaccharide followed the second and showed higher antitumor activity equivalent to cisplatin. In summary, the mushroom is a promising and potential source for screening natural antioxidants and antitumor agents.

Key words: butyl hydroxy anisd (BHA), 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH), cisplatin, MTT method, H446 cancer cell lines

CLC Number:

Q949.3

CHEN Ying1，SUN Hong2，ZHANG Shu-bin2，WANG Li-an2,*. Antioxidant and Anti-tumor Activities of Extracts from Lepista irina[J]. FOOD SCIENCE, 2009, 30(23): 214-217.

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Antioxidant and Anti-tumor Activities of Extracts from Lepista irina

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