Antioxidant Activity of Grape Seed Proanthocyanidin Extract in Aging Mouse Model

doi:10.7506/spkx1002-6630-201423049

Abstract

Abstract:

Objective: To study the antioxidant activity of grape seed proanthocyanidin extract (GSPE) in aging mice induced by
D-galactose. Methods: GSPE was extracted with cellulase and purified by macroporous resin adsorption. The aging ICR mouse
model induced by subcutaneous injection of D-galactose was orally administered with GSPE. The content of malondialdehyde
(MDA), the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and total antioxidant capacity (T-AOC)
in cerebrum, heart, liver and serum of the mice were assessed. Results: D-galactose could obviously reduce T-AOC as well as
SOD and GSH-Px activities, and enhance MDA contents in mouse cerebrum, heart, liver and serum. In contrast, GSPE could
significantly enhance T-AOC, and SOD and GSH-Px activities, and reduce MDA contents in serum, and cerebrum, heart and liver
tissues of the aging mice, especially in serum. Conclusion: GSPE could improve the activities of endogenous antioxidant enzymes
in aging mice. Therefore, it has good antioxidant and anti-aging effects.

Key words: grape seed proanthocyanidin extract, D-galactose, aged mice, antioxidation

CLC Number:

TS201.4

GAO Lu1, WANG Ying2, RAO Sheng-qi1, YANG Zhen-quan1, HUANG A-gen1, HU Bo-ran1,*. Antioxidant Activity of Grape Seed Proanthocyanidin Extract in Aging Mouse Model[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201423049.

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Antioxidant Activity of Grape Seed Proanthocyanidin Extract in Aging Mouse Model

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