Abstract: Currently, there is considerable interest in the utilization of flaxseed cake. The effect of partially defatted flaxseed meal (PDFM) processed from flaxseed cake on blood sugar levels in rats fed with a high-fat high-sugar diet was investigated in the present study. SD rats were divided into 6 groups (n = 9): normal, high-fat high-sugar model, acarbose treatment (positive control), low-dose PDFM (5% PDFM), middle-dose PDFM (10% PDFM) and high-dose PDFM (20% PDFM) groups. After intervention for 8 weeks, fasting blood glucose was measured, and glucose tolerance test was carried out. Then, the rats were sacrificed and dissected to observe the internal organs and determine liver index, pancreas index and abdominal fat index as well as glycosylated hemoglobin, liver glycogen and serum lipid. The results showed that 1) fasting blood glucose levels in the model, low-, medium-, and high-dose PDFM groups were (7.15 ± 1.22), (6.34 ± 0.48), (5.82 ± 0.36), and (5.03 ± 0.32) mmol/L, respectively, which were found to contain 5, 1, 0 and 0 rats with fasting blood glucose levels greater than 7.0 mmol/L, indicating that PDFM could inhibit hyperglycemia and diabetes development in high-fat highsugar diet fed rats, and the anti-hyperglycemia effect was highly dose dependent and significant in the middle- and high-dose groups compared with the model group (P < 0.05); 2) middle- and high-dose PDFM was as effective as acarbose in reducing reduced fasting blood glucose, which was (5.14 ± 0.33) mmol/L in the acarbose treatment group. Taking into consideration its effect on all above parameters, PDFM has great potential as an auxiliary hypoglycemic agent.

Key words: flaxseed cake, partially defatted flaxseed meal, animal test, blood glucose, glycosylated hemoglobin