食品科学 ›› 2010, Vol. 31 ›› Issue (8): 174-176.doi: 10.7506/spkx1002-6300-201008038

• 分析检测 • 上一篇    下一篇

食品接触材料中全氟烷基磺酸类化合物的HPLC-MS/MS测定

陈笑梅1,刘慧婷2,谢维斌1,郑自强1,朱晓雨1,赵珊红1,丁慧瑛1,王华雄1,蒋沁婷1   

  1. 1.浙江出入境检验检疫局 2.浙江大学生物系统工程与食品科学学院
  • 收稿日期:2009-06-09 修回日期:2009-11-16 出版日期:2010-04-15 发布日期:2010-12-29
  • 通讯作者: 蒋沁婷 E-mail:jqt@ziq.gov.cn
  • 基金资助:

    国家质量监督检验检疫总局质检公益性行业科研专项(10-64)

HPLC-MS/MS Determination of Perfluoroalkane Sulfonates in Food Contact Materials

CHEN Xiao-mei1,LIU Hui-ting2,XIE Wei-bin1,ZHENG Zi-qiang1,ZHU Xiao-yu1,ZHAO Shan-hong1,
DING Hui-ying1,WANG Hua-xiong1,JIANG Qin-ting1,*   

  1. 1. Zhejiang Entry-Exit Inspection and Quarantine Bureau, Hangzhou 310012, China ;
    2. College of Biosystem Engineering and Food Science, Zhejiang University, Hangzhou 310029, China
  • Received:2009-06-09 Revised:2009-11-16 Online:2010-04-15 Published:2010-12-29
  • Contact: JIANG Qin-ting1 E-mail:jqt@ziq.gov.cn

摘要:

研究食品接触材料中全氟烷基磺酸类化合物的检测方法和该类化合物的残留水平。样品采用甲醇超声提取,液相色谱- 质谱联用测定,以C18 为分离柱,甲醇-5mmol/L 乙酸铵溶液为梯度洗脱淋洗液,同位素内标法定量,内标物为13C 标记的PFOS。该方法的检出限为0.5μg/kg,线性范围为0.5~10μg/kg,方法的平均回收率为91.1%~112.8%。结果证明,该方法准确、快速,可成功应用于16 种食品接触材料实样的检测。

关键词: 食品接触材料, 全氟烷基磺酸, 液相色谱- 串联质谱法, 同位素内标法

Abstract:

An analytic method using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was developed for the determination of 4 perfluoroalkane sulfonates in food contact materials. Samples were extracted using methanol with ultrasonic assistance. The chromatographic separation was achieved on a C18 column using a mixture of methanol and a 5 mmol/L ammonium acetate aqueous solution as elution solvent for gradient elution. A 13C-labelled PFOS standard was used for the quantification of perfluoroalkane sulfonates. The developed method displayed a limit of detection of 0.5μg/kg and a linear range of 0.5-10μg/kg. Mean recoveries (6 replicates) for 4 perfluoroalkane sulfonates in a negative sample spiked at the levels of 1.0, 2.0μg/kg and 3.0μg/kg ranged from 91.1% to 112.8 %. This method proved to be an accurate and rapid method and was successfully used to detect 16 commercial food contact materials.

Key words: food contact materials, perfluoroalkane sulfonates, high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS), isotope-labeled internal standard method

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