FOOD SCIENCE ›› 2011, Vol. 32 ›› Issue (9): 266-271.doi: 10.7506/spkx1002-6630-201109059

• Nutrition & Hygiene • Previous Articles     Next Articles

Antitumor Activity of Polysaccharide WPS-1 Derived from Rapeseed Meal

ZHU Jian-fei1,2，TANG Chun-hong1,2，WU Mou-cheng3   

  1. 1. College of Environmental and Biological Engineering, Chongqing Technology and Business University, Chongqing 400067, China；2. Natural and Health Food Research Institute, Chongqing Technology and Business University, Chongqing 400067, China；3. College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China
  • Online:2011-05-15 Published:2011-04-11

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Abstract: A polysaccharide fraction was isolated and purified from rapeseed meal Huaza No.4 and named as WPS-1. The monosaccharide composition of WPS-1 was identified by HPLC, and its inhibitory effect on the in vitro and in vivo proliferation of Sarcoma-180 (S180) tumor cells was evaluated. Meanwhile, the effect on the immune response in S180-bearing mice was tested based on tumor weight, spleen weight, thymus weight, delayed-type hypersensitivity reaction to dinitrofluorobenzene (DNFB), the phagocytic capacity of peritoneal macrophages and splenocytes proliferation. Our findings indicates that WPS-1 have significant antitumor and immunomodulating functions.

Key words: polysaccharide, rapeseed meal, antitumor, immunological

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