Anti-mutagenic Effect of Water-soluble Polysaccharide from Hippophae rhamnoides Leaves

doi:10.7506/spkx1002-6630-201119048

Abstract

Abstract: In order to explore the anti-mutagenic effect of water-soluble polysaccharides from Hippophae rhamnoides leaves (WPHL), the inhibitory effect of WPHL on bone mouse marrow cell micronuclei, abnormal sperm and hepatic DNA damage induced by cyclophosphamide (CP) was studied. The results show that WPHL at the dose of 50 mg/kg ·d significantly inhibited the frequency of micronucleus (P <0.05) and sperm abnormality (P <0.05). In addition, WPHL could also significantly decrease the number and tail length of hepatic comet cells (P <0.05). Therefore, WPHL has anti-mutagenic potential.

Key words: Hippophae rhamnoides leaf, polysaccharide, anti-mutation, micronuclei test, comet assay

CLC Number:

Q946.91
R285.5

LI Fang-liang，GAO Yang，LIU Ying，YANG Xin-yuan，WANG Rui. Anti-mutagenic Effect of Water-soluble Polysaccharide from Hippophae rhamnoides Leaves[J]. FOOD SCIENCE, 2011, 32(19): 217-219.

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Anti-mutagenic Effect of Water-soluble Polysaccharide from Hippophae rhamnoides Leaves

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