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Polysaccharides from Morchella angusticeps Peck Inhibit Cell Proliferation and Induce Apoptosis in MDA-MB-231 Human Breast Cancer Cells

LI Yao1, CHEN Jinlong1, WANG Liying1, ZHANG Yueqiao1, WU Surui2, MING Jian1,3,*   

  1. 1. College of Food Science, Southwest University, Chongqing 400715, China;
    2. Kunming Edible Fungi Institute, All China Federation of Supply and Marketing Cooporatives, Kunming 650223, China;
    3. National Food Science and Engineering Experimental Teaching Center, Southwest University, Chongqing 400715, China
  • Online:2016-11-15 Published:2016-11-18

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Abstract:

The effects of polysaccharides from Morchella angusticeps Peck (PMEP) on the proliferation and apoptosis of
MDA-MB-231 human breast cancer cells were investigated in this study. The results showed that PMEP could significantly
inhibit the proliferation of MDA-MB-231 in the non-cytotoxic concentration range with a median effective concentration
(EC50) of 0.096 mg/mL. MDA-MB-231 cells also showed a series of morphological changes associated with apoptosis.
Western blotting assay showed that PMEP could inhibit the expression of B-cell lymphoma-2 (Bcl-2) protein, increase the
expression of Bcl-2 associated X protein (Bax) and Bax/Bcl-2 ratio in a dose-dependent manner. In conclusion, PMEP could
inhibit the proliferation and induce the apoptosis of MDA-MB-231 cells.

Key words: Morchella esculenta, polysaccharide, MDA-MB-231 human breast cancer cell, cell proliferation, cell apoptosis

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