关键词: 茶叶, 儿茶素, 茶黄素, 蛋白质, 聚集, 错误折叠

Abstract: Protein misfolding and aggregation can cause a series of diseases such as Alzheimer’s, Parkinson’s, Huntington’s diseases and type 2 diabetes by inducing the formation of toxic oligomer and amyloid fiber. In this article, recent in vivo and in vitro studies in this regard are summarized. We also review the literature on the inhibitory effects and mechanisms of functional components such as catechins and theaflavins in tea on protein aggregation as well as their effects in preventing and treating several typical protein misfolding diseases.

Key words: tea, catechin, theaflavins, protein, aggregation, misfolding