Abstract: This paper studied the effect of polysaccharide from Ampelopsis Grossedentata (AGP)on S180 tumor growth inhibition and immunoregulation in vivo. S180 cells were implanted into the axilla of normally growing mice by subcutaneous injection except the normal control mice. The mice were randomly divided into six groups and injected with physiological saline, cyclophosphamide and AGP into their intra-peritoneal respectively for 9 days , then the mice were killed and the indexes were detected , including the weight of tumor and immune organ, immune capability and the activity of serum lactic dehydrogenase(LDH), etc. Results showed that AGP could inhibit tumor growth in vivo and the inhibition rate was from 5.81% to 32.56% at 25～100 mg/kg·d of AGP. Compared with tumor-bearing control, the AGP at 50 and 100 mg/kg·d could remarkably enhance delayed-type hypersensitivity(DTH), macrophage phagocytic rate and phagocytic index, serum hemohysin content and splenic antibody formation, also, AGP could inhibit the activity of serum LDH, and increase the activity of catalase in erythrocyte(CAT)of S180-bearing mice(p<0.05, p<0.01). The conceivable mechanism of inhibiting tumor growth of AGP in vivo is by increasing the immunity and antioxidative capability of tumor-bearing mice.

Key words: polysaccharide from Ampelopsis Grossedentata(AGP), antitumor, immunoregulation