Identification and Determination of Illegal Adding of Sibutramine Hydrochloride in Diet Pills of Traditional Chinese Medicine for Health Care

Abstract

Abstract: To establish a method for identification and determination of illegal adding of chemical substance Sibutramine hydrochloride in the diet pills of traditional Chinese medicine for health care, TLC, HPLC-DAD and LC/MS/MS technology were employed to isolate and identify the Sibutramine hydrochloride. The content determination was made by HPLC. Among the 43 samples purchased from market, 9 samples contained Sibutramine hydrochloride. The method is specific, sensitive, convenient and the precision was satisfactory, and it can be used efficiently for control and surveillance of illegal adding of chemical substance Sibutramine hydrochloride in the diet pills of traditional chinese medicine for health care.

Key words: diet pills of traditional Chinese medicine for health care, Sibutramine hydrochloride, TLC, HPLC-DAD, LC/MS/MS

CAO Ling, ZHANG Yu-Lin, WANG Bao-Zhu. Identification and Determination of Illegal Adding of Sibutramine Hydrochloride in Diet Pills of Traditional Chinese Medicine for Health Care[J]. FOOD SCIENCE, 2008, 29(2): 340-343.

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Identification and Determination of Illegal Adding of Sibutramine Hydrochloride in Diet Pills of Traditional Chinese Medicine for Health Care

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