FOOD SCIENCE ›› 2008, Vol. 29 ›› Issue (9): 580-584.

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Effects of Conjugated Linoleic Acids on Fatty Acid Composition in Atherosclerotic Tissues of Rats

 FAN  Ya-Wei, DENG  Ze-Yuan, LI  Jing   

  1. State Key Laboratory of Food Science and Technology,Department of Food Science and Engineering,Nanchang University,Nanchang 330047,China
  • Online:2008-09-15 Published:2011-12-08

Abstract: The aim of this study was to determine the changes in fatty acid composition, in particular n-3 and n-6 polyunsaturated fatty acids (PUFA) in rat kidney, liver, heart and brain to assess and compare the effects of conjugated linoleic acids(CLA) supplementation. The fatty acid composition in the various tissues of aged atherosclerotic rats was determined and compared. The aged rats were fed with high lipid. They were randomly divided into three groups: low dose (0.5g/kg bw·d), middle dose (1.25 g/kg bw·d) and high dose (2.5 g/kg bw·d) of CLA in diet and control group. The contents of fatty acids in rats tissues were determined. Tissue compositions of total n-3 PUFA increase in brain, liver and kidney of rats fed CLA. The compositions of total n-6 PUFA and n-6/n-3 values decrease in liver and heart tissues of rats fed with CLA. CLA may substitute partial n- 6PUFA in the tissues. Accumulations of CLA are various in the various tissues. The CLA content in heart reaches 15.77 %, but the CLA content in brain is only 0.22%~0.53%.All these indicated that CLA can influence the fatty acid composition and content in tissues on the atherosclerosis rat.

Key words: conjugated linoleic acid, aged rats, tissues, fatty acids