Effects of Cultured Cordyceps militaris-Ganoderma lucidum Spore Complex on Immune Function in Mice

Abstract

Abstract: Objective: To study the modulatory effect of cultured Cordyceps militaris-Ganoderma lucidum spore complex on the immune function of mice. Methods: In this study, mice were orally administered with the complex at low, medium and high doses for 30 days. After the last administration, mouse body weight, immune organ indices, delayed-type hypersensitivity (DTH), T lymphocyte proliferation induced by ConA, serum hemolysin formation, carbon clearance capability and the chicken red blood cell phagocytosis ability of mouse macrophages were assayed. Results: Compared with the control group, the high-dose treatment group significantly improved the body weight and thymus index of mice, the low- and medium- dose treatment groups showed a significant increase in delayed-type hypersensitivity, and the high-dose treatment group significantly enhanced the ability of ConA induced lymphocyte proliferation. These findings suggest that cultured Cordyceps militaris-Ganoderma lucidum spore complex can enhance specific immune responses in mice. Moreover, both the low and medium doses could also significantly enhance mouse carbon clearance capability and the chicken red blood cell phagocytosis ability of mouse macrophages, suggesting that the complex can enhance non-specific immune responses in mice. Conclusions: Cultured Cordyceps militaris-Ganoderma lucidum spore complex can enhance specific immune response and non-specific immune responses in mice, thus enhancing the immune system function of mice.

Key words: Cordyceps militaris, Ganoderma lucidum spores, immume modulation

CLC Number:

中图分类号：S567.3

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