FOOD SCIENCE ›› 2018, Vol. 39 ›› Issue (1): 178-184.doi: 10.7506/spkx1002-6630-201801027

• Nutrition & Hygiene • Previous Articles     Next Articles

Protective Effect of Active Peptide-N on D-Galactose-Induced Aging in Mice

CHEN Yu1, LIU Hongji1,2, YOU Qianqian1, YUAN Jinglin1, SONG Qi1, HAO Dan1, LIU Dong1, LAN Haijing1, LI Quanyang1,*   

  1. 1. College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China;2. JE Flow Tech (Shanghai) Co. Ltd., Shanghai 201404, China
  • Online:2018-01-15 Published:2018-01-05

Abstract: Herein, we evaluated the effect of active peptide-N as a new anti-aging agent on aging model mice. For this purpose, an aging model was established by subcutaneously injecting mice with D-galactose (200 mg/(kg·d)) once daily for nine weeks. Thereafter, the mice was separately orally administered with multiple emulsion containing active peptide-N at doses of 2.5, 25.0 and 125.0 μg/ (kg·d). The open field and the Morris water maze test were used to evaluate the locomotor activity and learning and memory ability of mice. Furthermore, glutathione peroxidase (GSH-Px) activity and malondialdehyde (MDA) content in the serum, and acetyl cholinesterase (AChE) activity in the brain tissue of mice were measured. The results showed that active peptide-N multiple emulsion could significantly improve the locomotor activity and learning and memory ability of D-galactose-induced aging mice. The activity of serum GSH-Px was improved by 28.38% (P < 0.05), the concentration of serum MDA was decreased by 26.19% (P < 0.05), and the brain AChE activity was increased by 23.26% in the treated groups (P < 0.05) compared with the aging model group. These results demonstrate that active peptide-N multiple emulsion has an obvious anti-aging effect in D-galactose-induced aging mice.

Key words: active peptide-N multiple emulsion, D-galactose, anti-aging, learning and memory

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