In order to explain cross-reactivity between peanut allergen Ara h 6 and other homologous proteins, various kinds of bioinformationcal databases, including Genbank and DiscoTope, and net tools/software, including BLAST, NPS@, Protean, Clustal x and PyMOL, were used for the epitope analysis between these proteins. It was indicated that the linear epitopes on Ara h 6 existed with high probability in the regions of AA10-15, 45 -48, 53 -60 and 116 -118, and the conformational epitopes in the regions of AA1-13, 35-51, 53-59 and 89-105. According to the prediction of linear epitopes, there were fifteen proteins might cross-react with Ara h 6, and the possibility of cross-reactivity of four of them (Ara i 6, conglutin, Ara d 6 and conglutin 8) was 100%. However, according to the prediction of conformational epitopes, the number of proteins could cross-react with Ara h 6 with high probability was 17, and the possibility of cross-reactivity of four of them (Ara i 6, conglutin, Ara d 6 and conglutin 8) was 100%. These investigations will be beneficial for understanding peanut Ara h 6 allergy and help to develop an approach for the immunologic detection of Ara h 6 in foods in the future.